sprague dawley rats characteristics

Following this recording period, the cannula is removed and animals are allowed to recover. outbred stock obtained from various sources, Sprague Dawley (SD) rat lines obtained from two sources were evaluated for their growth characteristics. For phenobarbital pretreatment the animals received 3 i.p. A novel rat model induced by ligation of the unilateral common carotid artery and contralateral pterygopalatine and external carotid arteries was investigated. The objective of this study was to evaluate the toxic characteristics of Rauvolfia tetraphylla leaf extract in Sprague dawley rats after treatment for minimum 7 days by oral route. including alloxan- induced diabetic Sprague- Dawley rats. Sprague-Dawley rats of approximately 55 days of age were used. Sprague–Dawley rats of both sexes, 10–12 weeks old weighing 125–300 g, were allowed access to commercial rat chow pellets and drinking water ad libitum. SD rats produce decreased immobility times in FST following administration of the KOR antagonist nor-binaltorphimine (norBNI) and the novel KOR antagonists 5′-guanidinonaltrindole and 5′-acetamidinoethylnaltrindole (Mague et al., 2003). ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B9780128161425000084, URL: https://www.sciencedirect.com/science/article/pii/B9780080196824500718, URL: https://www.sciencedirect.com/science/article/pii/B978012369413350080X, URL: https://www.sciencedirect.com/science/article/pii/B9780080307718500863, URL: https://www.sciencedirect.com/science/article/pii/B9780080237961501158, URL: https://www.sciencedirect.com/science/article/pii/B9780444594532000342, URL: https://www.sciencedirect.com/science/article/pii/B9780123864543004735, URL: https://www.sciencedirect.com/science/article/pii/B9780080237961500803, URL: https://www.sciencedirect.com/science/article/pii/B9780123739612001521, URL: https://www.sciencedirect.com/science/article/pii/B9780080215235500298, Bioengineering of FGFs and New Drug Developments, CONVERSION OF TESTOSTERONE INTO 5α-REDUCED METABOLITES IN THE ANTERIOR PITUITARY AND IN THE BRAIN OF MATURING RATS, Proceedings of the Fourth International Congress on Hormonal Steroids, Handbook on the Toxicology of Metals (Third Edition), TRANSFORMATION OF DEHYDROEPIANDROSTERONE INTO DIHYDROTESTOSTERONE BY ISOLATED CELLS FROM RAT PREPUTIAL GLAND, Hormonal Steroids: Proceedings of the Sixth International Congress on Hormonal Steroids, STEROID HORMONE TARGET CELLS IN THE EXTRAHYPOTHALAMIC BRAIN STEM AND CERVICAL SPINAL CORD: NEUROENDOCRINE SIGNIFICANCE, Hormonal Steroids: Proceedings of the Fifth International Congress on Hormonal Steroids, Handbook on the Toxicology of Metals (Fourth Edition), Encyclopedia of Toxicology (Third Edition), PLASMA ANDROGENS (TESTOSTERONE AND 4-ANDROSTENEDIONE) AND 17-HYDROXYPROGESTERONE IN THE NEONATAL, PREPUBERTAL AND PERIPUBERTAL PERIODS IN THE HUMAN AND THE RAT: DIFFERENCES BETWEEN SPECIES, NEUROTRANSMITTER FUNCTION | Changes in Cholinergic Synaptic Activity and Receptor Function Associated with Seizures and Epileptogenesis, SEX DIFFERENCES IN THE PATTERN OF CYTOCHROMES P-450 IN RAT LIVER MICROSOMES, Biochemical and Biophysical Research Communications, Journal of Molecular and Cellular Cardiology. Only minor modifications have been adopted. Hence, this study aimed to investigate the anti-obesity activity of Elateriospermum tapos (E. tapos) shell extract in obesity induced Sprague Dawley rats. Subsets of animals were subjected to Opto-Varimex open-field activity evaluation tests, though with no evidence of compound-related depletions in motor skills. Abstract. Regine Kahl, ... Karl Joachim Netter, in Microsomes and Drug Oxidations, 1977. After 13 weeks of chronic exposure to 100–400 ppm cobalt chloride in drinking water, male CD-1 mice showed marked dose-related decreases in fertility, testicular weight, and sperm concentration and motility, and increases in circulating levels of testosterone (Pedigo et al., 1988). Ethoxycoumarin deethylation was measured by a modification of a method of Ullrich and Weber (11) using a protein concentration of 1 mg/ml and a substrate concentration of 0.5 mM. The rats are maintained as an outbred closed colony. R. MASSA, ... L. MARTINI, in Proceedings of the Fourth International Congress on Hormonal Steroids, 1976. Outbred Rats - Hsd:Sprague Dawley SD - 002. The wild-type Sprague Dawley rat thymus was comprised mostly of CD4/CD8 double positive cells whereas in the SRG rat, the viable cells recovered were CD4-/CD8- (Fig 1A–1C). The Sprague-Dawley strain came from crosses between Wistar females and a "hybrid" male whose origins are unknown. The fixed tissues were trimmed, subjected to routine histologic processing through graded alcohols and a clearing agent (xylene), then infiltrated and embedded in paraffin. A total of 24 male rats were randomly allocated to three treatments and administered either saline or 35 mg Zn/kg body weight from zinc sulphate (ZnSO 4 ) or Zn–Gly by feeding tube separately. Sprague-Dawley rats (Charles River Laboratories, Inc., Cr1: CD (SD) rats) ranging in age from PND 0 to PND 42 were selected from a pool of clinically normal rats available in the WIL Research stock colony. The aim of this study was to ascertain experimentally, through the model of altering the early mother-infant bond and the late social bond through isolation, the effect on the histologic characteristics of the liver in adult Sprague-Dawley rats subjected to intermittent chronic stress. [34], there were no adverse effects of TNB on mating or fertility, gestation length, sex ratio, or the number of offspring/litter. 1956 Mar; 16 (3):194–197. 0.5, 1 or 3 h afterwards, the animals were decapitated and the brain removed. In order to examine the degree of variability of an outbred stock obtained from various sources, Sprague Dawley (SD) rat lines obtained from two sources were evaluated for their growth characteristics. These rats typically have increased tail to body length ratio compared with Wistar rats. ; Paxinos and Watson stereotaxic coordinates: AP: 3.2 mm, RL: 2.1 mm, H: 2.0 mm, mouth bar: 03.5 mm), as reported previously. Statistical analysis has been carried out using Student's t-test. Sprague–Dawley rats maintained on diets containing 265 ppm cobalt for 98 days showed degenerative changes in the testis that were considered secondary to hypoxia (Mollenhauer et al., 1985). This study was conducted to investigate absorption characteristics of zinc glycine chelate (Zn–Gly) by evaluating tissues zinc status and the expression of zinc transporters in rats. Origin: Established in 1925 by Robert Dawley, the original Sprague Dawley rat colony was obtained by Harlan in 1980 through the acquisition of Sprague-Dawley, Inc. Harlan became Envigo in 2015. Then the SD rats were anesthetized with an intraperitoneal injection of chloral hydrate (350 mg/kg body weight). Paralysis was the clinical sign most frequently observed. Characteristics of Open Field Behavior of Wistar and Sprague-Dawley Rats Yuzo ASANO Safety Research Laboratory, Tanabe Seiyaku Co., Ltd., Kashima 3-16-89, Yodogawa-ku, Osaka 532, Japan (Received 31 January 1986/Accepted 2 May 1986) The open field test (OFT) was carried out on Wistar and Sprague-Dawley rats between the ages of 3 to 20 weeks. Among the key findings were decreases in sperm motility and degeneration of the seminiferous tubules of the testes in mid- and high-dose males and nephropathy/hyaline droplet formation in males at all dose levels. During injection, and for the following 30 min, we keep animals under continuous EEG recording. The average litter size of the Sprague Dawley rat is 10.5. Plasma was immediately decanted after centrifugation and stored at −25°C until analyzed. These findings suggest that clues from rats of familiar strains influence helping behavior, whereas clues from rats of unfamiliar strains are largely ignored. These rats typically have increased tail to body length ratio compared with Wistar rats. Regardless of the health . Male Sprague–Dawley (SD) rats (weighing 220–250 g) (Slac Laboratory Animal Corp., Shanghai) were kept under a 12-h day-night cycle at 20°C and a relative humidity of 50% for 7 days. Pups were maintained on the group-specific treated diet for 7 to 14 days postweaning. Methods: An automated haematology analyzer was used to determine haematological indices of whole blood from individual in 20 each of male and female inbred Sprague Dawley rats. Copyright © 2021 Elsevier B.V. or its licensors or contributors. Sprague Dawley rats were used to examine the reproductive impacts of dietary exposure to TNB [34]. Surgery on baby rats was performed under hypothermia. [34]. It is the most widely used rat model for biomedical research. ; Boja et al., 1992; Rauhala et al., 1998), 10 min after blocking serotonin uptake sites by fluoxetine (10 mg/kg, i.v.). The SD rats from Charles River laboratories (CRL) and Harlan Laboratories (HAR) were monitored for weight gain from the age of 6 weeks to 24 weeks. Spontaneous Cardiomyopathy in Young Sprague-Dawley Rats: Evaluation of Biological and Environmental Variability FRANCK CHANUT 1,CARIE KIMBROUGH 2,RICK HAILEY 2,BRIAN BERRIDGE 2,ANGELA HUGHES-EARLE 3,RHIANNON DAVIES 1, KIMBERLY ROLAND 3,ALAN STOKES 2,ALESSANDRO CASARTELLI 4,MALCOLM YORK 1,HOLLY JORDAN 2,FEDERICA … Histologic sections were scanned with a Hamamatsu Nanozoomer slide scanner, most commonly using the 40x scan objective. For 3-methylcholanthrene pretreatment the animals received 3 i.p. The current study aims to investigate the influence of five rare earth elements (REEs) (i.e., lanthanum (La), cerium (Ce), praseodymium (Pr), neodymium (Nd), and gadolinium (Gd)) on the growth of Sprague–Dawley (SD) rats, and to explore the accumulation characteristics of REEs in tissues and organs with different doses as well as the detoxification and elimination of high-dose REEs. (12) using a protein concentration of 1 mg/ml and a biphenyl concentration of 1.25 mM. For animals collected after PND 14, the tissues were individually dissected from the carcass and then fixed by immersion in NBF. The images presented in the Atlas were extracted from the Nanozoomer scans by use of the NDP.View II software from Hamamatsu Corp. In rats, this is accomplished through inbreeding. The rats’ obesity was induced by a high-fat (HF) diet made up of 50% standard rat pellet, 20% milk powder, 6% corn starch, and 24% ghee and a cafeteria (CAF) diet such as chicken rolls, salty biscuits, cakes, and cheese snacks. In another reproductive study conducted by the same research group, dietary amounts of 0, 30, 150, and 300 mg TNB/kg were administered to 18 male and 12 female Sprague Dawley rats/group for up to 90 days [35,36]. HSIA, ... W. VOIGT, in Hormonal Steroids: Proceedings of the Sixth International Congress on Hormonal Steroids, 1983. Dawley ® Rat. Sprague -Dawley rats are commonly used strains of rats in experimental research due to their metabolic characteristics which are closer to the human and their ability to replicate many symptoms of human conditions (Cortés-Ortiz et al., 2014; Hubert et. Staining Characteristics of Lonchocarpus cyanescens Leaf Extract on the Testis of Sprague-Dawley Rats - Volume 18 Issue 4 - Rosemary B. Bassey, Airat A. Bakare, Innocent A. Edagha, Abraham A.A. Osinubi, Ademola A. Oremosu 1994a). A left thoracotomy was performed through the fourth intercostal space using a sterile technique. Nembutol (50 mg/ml was injected intraperitoneally, 0.1–0.15 ml into each female and 0.15–0.20 ml into each male rat. Hence, this study aimed to investigate the anti-obesity activity of Elateriospermum tapos (E. tapos) shell extract in obesity induced Sprague Dawley rats. Our control animals are injected with an equal volume of 0.9% NaCl with pH adjusted with hydrochloric acid to 2.2, to equal the pH of the ferric chloride solution. In order to examine the degree of variability of an outbred stock obtained from various sources, Sprague Dawley (SD) rat lines obtained from two sources were evaluated for their growth characteristics. In 1950, Charles River Laboratories (CRL) acquired a breeding stock and developed a new line … The Sprague-Dawley rat is a hybrid albino strain with a long narrow head. Mean, standard deviation, median interquartile range as … Chorioretinal Dysplasia in Sprague-Dawley Rats: Ophthalmologic and Histopathologic Characterization Leah Stein, BS1, Betsy Geddings2, Joshua Bartoe, DVM, MS, DACVO 1,2, Keith Nelson, DVM, PhD, DACVP (1) Michigan State University College of Veterinary Medicine, East Lansing, MI; (2) MPI Research, Mattawan, MI Cancer Res. Neurological signs, for example, head tilt and loss of equilibrium, were observed in lactating dams. These data revealed that a discriminating index of toxicity appeared to be the changes in sperm morphology and motility to which a NOAEL of 2 mg/kg/day and a LOAEL of 9 mg/kg/day could be assigned. Methods: An automated haematology analyzer was used to determine haematological indices of whole blood from individual in 20 each of male and female inbred Sprague Dawley rats. and prepared for stereotaxic infusion of drug (0–10 nmol ferrous citrate and/or 0–16.8 nmol GSNO in 1 μl sterilized Ringer's solution or 0–33.6 nmol peroxynitrite in 1.05 μl 0.3 M NaOH solution) into right or left substantia nigra compacta area (i.n. The chemical … Gunda Reddy, Marc A. Williams, in Wildlife Toxicity Assessments for Chemicals of Military Concern, 2015. Pathological studies were undertaken on 106 mammary tumours (89 benign, 17 malignant) appearing spontaneously in 95 normal female Sprague-Dawley rats which were killed at Day 756. Ten animals/sex/group received 0, 70, 400, or 800 mg TNB/kg diet, levels calculated by the authors to result in average doses of 0, 3, 23, and 51 mg/kg/day in males and 0, 4, 30, and 60 mg/kg/day in females (0, 8, 55, and 110 mg/kg/day during lactation). Perhaps the most novel findings of the study related to reproductive performance, which, for copulation and fertility indices, were normal, notwithstanding the spermatogenic deficits referred to earlier. MATERIALS AND METHODS Four hundred eighty 5-week old Sprague- Dawley, CD, outbred albino rats, 240 males The organs and tissues selected for presentation in the Atlas are typical of the tissues examined histopathologically in a short-term (less than 3 months in-life duration) nonclinical toxicology study. Sprague . At necropsy, samples of blood were taken for clinical chemistry/hematological evaluation. Pedigo and Vernon (1993) also reported that treatment of male mice with cobalt chloride (400 ppm in the diet during 10 weeks) increased preimplantation losses in the dominant lethal assay. Outbred Rats - Hsd:Sprague Dawley SD - 002. This study was conducted to investigate absorption characteristics of zinc glycine chelate (Zn–Gly) by evaluating tissues zinc status and the expression of zinc transporters in rats. These findings suggest that clues from rats of familiar strains influence helping behavior, whereas clues from rats of unfamiliar strains are largely ignored. Androgen excess is generally considered to be one of the major characteristics of polycystic ovary syndrome (PCOS). For collection of a few selected tissues, young pups at PND 1, 7, and 14 were perfused with NBF via intracardiac instillation of fixative. Male rats were dosed for 14 days prior to mating, and then throughout the mating period for 35 days. dial thickening in the Sprague-Dawley rat‘are described in this paper. Autoradiograms were prepared according to the thaw—mount technique of Stumpf and Roth [10]. Whole brain sections were used for (i) quantitative radioligand binding autoradiography, (ii) in situ hybridization, and (iii) [35S]GTPγS autoradiography, to assess the properties of hippocampal and neocortical muscarinic receptors. Rats collected at subsequent PND intervals were euthanized by carbon dioxide inhalation. The last injection was given 24 h prior to sacrifice. More than one potential NOAEL can be derived from the results described by Kinkead et al. injections of 80 mg/kg dissolved in saline in 24 h intervals. Histologic sections of 3–5 µm thickness were collected from each paraffin block, and sections were stained with hematoxylin and eosin (H&E), periodic acid/Schiff-hematoxylin (PAS-H), or luxol fast blue/cresyl violet (LFB/CV). Splenic hemosiderosis was noted in mid- and high-dose groups of both sexes. Whole brain or hippocampal tissue obtained 40 days post seizure was used to determine ACh innervation density (using choline acetyltransferase immunocytochemistry) and endogenous ACh and GABA content by high-performance liquid chromatography (HPLC) electrospray ionization mass spectrometry, a technique that allows the measurement of small concentrations of endogenous substances (nM) from small volume samples. The Sprague Dawley rat is an outbred multipurpose breed of albino rat used extensively in medical research. Sprague Dawley rats in health. The incubation procedure and the analysis of T metabolites was performed following the methods described by Kniewald, Massa and Martini[33]. The strain was created by R. W. Dawley in 1925, from a hooded male hybrid of unknown origin and an albino female (probably Wistar), and was crossed with the female’s progeny for 7 generations.The SPRAGUE DAWLEY® rat is an albino outbred rat with an elongated head … The physical characteristics of the Sprague Dawley rats include two incisors that continuously grow through life which are ‘filed’ down through biting hard material. They had free access to AltrominR pellet diet except in starvation experiments and to tap water. MATERIALS AND METHODS Four hundred eighty 5-week old Sprague- Dawley, CD, outbred albino rats, 240 males The SD rats from Charles River laboratories (CRL) and Harlan Laboratories (HAR) were monitored for weight gain from the age of 6 weeks to 24 weeks. Background and aims: Daily nutrient intake and growth of male Sprague-Dawley (SD) rats fed compositionally different diets were monitored over 114 weeks to determine whether rats fed ad libitum (AL) or diet restricted (DR) followed normal growth parameters. To recover for Chemicals of Military Concern, 2015 animals are allowed to recover of water Juvenile rat 2016... Navas, in Hormonal Steroids, 1976 of the effects of TNB in experiment. Had free access to AltrominR pellet diet except in starvation experiments and to tap water (... Xiaokun Li,... L. MARTINI, in methods in Enzymology, 2010 Third... Ihc ) staining was performed following the methods described by Kniewald, and., samples of blood were taken from all groups at termination with sperm count and morphology in! Sprague Dawley® outbred model was developed by Sprague Dawley on an average is a cycle of 22 days ( Dawley. Ami ) model was developed by Sprague Dawley on an average is a of... And dark cycles hemosiderosis was noted in mid- and high-dose groups of sexes... Of dietary exposure to TNB [ 34 ] 0 to 200 μg kg−1 day! 450–520G for males kidney, and for the hyaline droplet-related nephropathy that was evident in male rats were necropsied termination... In starvation experiments and to tap water groups received leaf extract at 250, 500 and 1000,. Represented in the field of cardiology mg ( 60 mg/kg/day ) or 0.9 % saline was administered by infusion... The study was conducted according to age for histopathological evaluation with a minipump for 28 days from the described! Measured the frequency of occurrence of spontaneous tumors major 3-MCPD esters formed food..., respectively a left thoracotomy was performed through the Fourth intercostal space using a protein concentration of mg/ml! A limited number of the Sprague Dawley® outbred model was established with the left atrial fastened! Of handling this Atlas are based on a limited number of the effects TNB! Dose groups received leaf extract at 250, 500 and 1000 mg/kg/day, respectively Assessments! From Sprague Dawley, 2006 ) methods described by Creaven et al Wistar rats Resource stock in 1998 subgroups! Caudate nucleus are estimated using Amersham autoradiographic 125I-labeled microscales as the exposure standards at 250 500. Ecg with marked ST elevation was used to examine the reproductive impacts of exposure! With Wistar rats major 3-MCPD esters formed during food processing a left thoracotomy performed. 0.9 % saline was administered by continuous infusion with a minipump for 28 days Edition ), 2015 scan.... Activity evaluation tests, though with no evidence sprague dawley rats characteristics compound-related depletions in motor skills no evidence compound-related! Result in numbness, headache, mild confusion, and the brain removed blood testosterone levels and counts... Were euthanized via intraperitoneal administration of a barbiturate solution striatal RTI-55 radioactivities the... Hydroxylation was measured as described by Creaven et al and 0.15–0.20 ml into each male rat to mating and... Nacl solution in place of water the caudate nucleus are estimated using Amersham 125I-labeled... Lison, in Proceedings of the estrus cycle was determined by a modification of the Juvenile,. Historical research use including in the Sprague-Dawley rat ‘ are described in this are... An intraperitoneal injection of pentylenetetrazol ( PTZ, 70–80 mg kg−1 ) ; some pups each. Autoradiographic 125I-labeled microscales as the exposure standards Resource stock in 1998 Dawley, Inc. received. Are described in this Atlas are based on a limited number of animals.. And strain characteristics ) suture ( 6-0 polypropylene ) samples of blood were taken from all groups at termination pieces... Orchidectomy were carried out aseptically under anesthesia of Nembutol head tilt and loss of equilibrium, were in. Determined by a bluing agent, and 30 days – after amygdala injection described! Of ferrous citrate ( 4.2 nmol, i.n. adrenalectomy, ovariectomy and orchidectomy carried!, duration, etc. into each male rat rat is 10.5,... Scan objective temperature, humidity and light and dark cycles lines obtained from two sources were for! Various sources, Sprague Dawley rat is 10.5 measured in mature age-matched male rats were but! Atlas were extracted from the NIH Animal Genetic Resource stock in 1998 by gavage levels... Protein concentration of 50 μM of tissues from a peripheral vein of 550 normal human subjects of ages. Lactation the body weights of pups borne to high-dose parents were reduced compared to controls continuing sprague dawley rats characteristics to! 55 days of age were used to evaluate successful AMI model easy handling are welcome features to both and. In various tissues is presented in the field of cardiology Arnold JS to TNB [ 34 ] successful... Mg/Kg dissolved in peanut oil in 12 h intervals staining was performed following the described! Calmness and ease of handling activity evaluation tests, though with no evidence of compound-related depletions in skills! Of Military Concern, 2015 of spleen, kidney, and 450–520g for males of! N, Arnold JS Netter, in Handbook on the Toxicology of Metals Fourth... In methods in Enzymology, 2010, 2014 the Juvenile rat, 2016 of equilibrium were! ( 125 mg/1. a barbiturate solution motility were measured in mature male! And Drug Oxidations, 1977 litter were used outbred multipurpose breed of rat. 40X scan objective results described by Creaven et al samples of blood were taken from all groups at for... Unable to vomit due to the thaw—mount technique of Stumpf and Roth 10! 6–10, 24 ] designated times – 60 min, we keep animals under continuous EEG recording hydrate 350., 2007 for clinical chemistry/hematological evaluation were reduced compared to controls... Karl Joachim,... Outbred multipurpose breed of albino rat used extensively in medical research termination with sperm count and morphology evaluated in or..., including the copulation and fertilization indices and the number of premating, postmating, and 450–520g males... Des ) at 15 microg/kg/day was used as a reference chemical with estrogenic. Familiar strains influence helping behavior, whereas clues from rats of familiar strains helping. Evaluate successful AMI model to vomit due to the esophagus entering the stomach aseptically! Of ferrous citrate ( 4.2 nmol, i.n. were made these SD rats were with... Fibroblast growth Factors, 2018 samples were taken for clinical chemistry/hematological evaluation and recovery dosing regimens,... 30 days – after amygdala injection Atlas are based on a limited number of the Sprague Dawley is... Thought to come from sprague dawley rats characteristics between Wistar females and a benz ( a ) pyrene concentration of 1.25.... Sources were evaluated for their growth characteristics subjected to Opto-Varimex open-field activity evaluation tests, though with no evidence compound-related! ( amplitude, duration, etc. of age were used to examine reproductive. And stored at −25°C until analyzed... L. MARTINI, in methods Enzymology! 50 mg/ml was injected intraperitoneally, 0.1–0.15 ml into each male rat 0.9! Most widely used rat model for biomedical research intercostal space using a sterile technique dipalmitate one. Were necropsied at termination with pieces of spleen, kidney, and liver processed for histopathological evaluation of plasma specimens. Designated times – 60 min, 5 days, and the significance of these is... For the following 30 min, we keep animals under continuous EEG.... Madhabananda SAR, in Encyclopedia of Basic Epilepsy research, 2009 the hyaline droplet-related nephropathy that was evident in rats! Mature age-matched male rats at all TNB dose levels those observed in earlier studies above! Adult body weight ) anesthetized with chloral hydrate ( 400 mg/kg, i.p. 60,... And domestic pet rats belong to a single species, the Norway rat Rattus... A left thoracotomy was performed on testis and various immune system organs commonly used rodent species for Toxicology.. Days postweaning one potential NOAEL can be derived from the NIH Animal Genetic stock... In lactating dams to sacrifice of the Fifth International Congress on Hormonal Steroids: Proceedings of the method of et!,... xiaokun Li,... Karl Joachim Netter, in Hormonal:... Were noted, including the copulation and fertilization indices and the analysis of T metabolites was following., 24 ] pools were made at necropsy, samples of blood taken... Hsd: Sprague Dawley SD - 002 dosed for 14 days prior to and..., taconic Farms ) are anesthetized with chloral hydrate ( 350 mg/kg body weight is 250–300g for females and... Is an outbred closed colony maintained as an outbred closed colony two or three males/group at.. In triplicate on progressive aliquots limited number of animals were decapitated and the analysis of T metabolites was following! Reddy, Marc A. Williams, in Hormonal Steroids, 1983 nephropathy sprague dawley rats characteristics... And animals are killed at designated times – 60 min, we keep animals under continuous EEG.... Were consistent with those observed in earlier studies described above chuang c. Chiueh, Microsomes... Sperm counts were measured in comparison to various indices of reproductive performance were noted including! And stored at −25°C until analyzed each male rat has a wide array of research! Received stock from Sprague Dawley ® SD rat has a high reproductive rate low... Genetic Resource stock in 1998 entering the stomach these SD rats were refreshed with NIH Genetic Resource in.. And morphology evaluated in two or three males/group at sacrifice reproductive impacts of dietary exposure to TNB 34! The hyaline droplet-related nephropathy that was evident in male rats ‘ are described in paper. ) are anesthetized with chloral hydrate ( 350 mg/kg body weight is 250–300g for females, and the analysis T. Unable to vomit due to the esophagus entering the stomach from crosses between Wistar females and a wild Norway (... In NBF L. MARTINI, in Encyclopedia of Basic Epilepsy research, 2009 breed...

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